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Abstract #0831

T2*-weighted MRI as a non-contrast enhanced method for assessment of focal laser ablation zone extent in prostate cancer thermotherapy

Chongpeng Sun1,2, Shiyang Wang1,3, Aritrick Chatterjee1, Milica Medved1, Scott Eggener4, Gregory S Karczmar1, and Aytekin Oto1
1Radiology, University of Chicago, Chicago, IL, United States, 2Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, 3Medical Physics, University of Missouri, Columbia, MO, United States, 4Urology, University of Chicago, Chicago, IL, United States

This study evaluated the utility of T2*-weighted (T2*W) MRI for intra-operative identification of ablation zone extent during focal laser ablation (FLA) of prostate cancer. Ablation zone ROI sizes and contrast-to-background ratio (CBR) were calculated on T2*W and apparent diffusion coefficient (ADC) maps and compared to those in the reference standard subtracted contrast-enhanced T1-weighted (sceT1W) images. CBRs on T2*W (TE=32,63 ms) did not differ significantly from those in sceT1W, and ROI sizes in T2*W (TE=63 ms) and sceT1W were well-correlated and differed by only 15%. Therefore, T2*W MRI with long TE visualizes post-procedure ablation zone comparably to contrast-enhanced T1W MRI.

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