Abstract #0831

T2*-weighted MRI as a non-contrast enhanced method for assessment of focal laser ablation zone extent in prostate cancer thermotherapy

Chongpeng Sun^1,2, Shiyang Wang^1,3, Aritrick Chatterjee¹, Milica Medved¹, Scott Eggener⁴, Gregory S Karczmar¹, and Aytekin Oto¹

¹Radiology, University of Chicago, Chicago, IL, United States, ²Radiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China, ³Medical Physics, University of Missouri, Columbia, MO, United States, ⁴Urology, University of Chicago, Chicago, IL, United States

This study evaluated the utility of T2*-weighted (T2*W) MRI for intra-operative identification of ablation zone extent during focal laser ablation (FLA) of prostate cancer. Ablation zone ROI sizes and contrast-to-background ratio (CBR) were calculated on T2*W and apparent diffusion coefficient (ADC) maps and compared to those in the reference standard subtracted contrast-enhanced T1-weighted (sceT1W) images. CBRs on T2*W (TE=32,63 ms) did not differ significantly from those in sceT1W, and ROI sizes in T2*W (TE=63 ms) and sceT1W were well-correlated and differed by only 15%. Therefore, T2*W MRI with long TE visualizes post-procedure ablation zone comparably to contrast-enhanced T1W MRI.

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