The utility of multiparametric (mp) versus biparametric (bp) MRI protocol in prostate cancer diagnosis has been compared in several large studies, but mainly using manual qualitative evaluation. In this study we employed machine learning models to investigate the added value of DCE (i.e. mpMRI) in predicting significant cancer foci in pre-biopsy MR images. Whereas both protocols had comparable results in the whole prostate and transition zone analyses, we found mpMRI model to be more useful in the peripheral zone, where significant differences (p < 0.05) were found for all performance measures i.e. area under the curve, accuracy, sensitivity and specificity.