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Abstract #0847

Characterizing extracellular diffusion properties using diffusion-weighted MRS of sucrose injected in the mouse brain

Mélissa Vincent1,2, Mylène Gaudin1,2, Covadonga Lucas-Torres3, Océane Guillemaud1,2, Carole Escartin1,2, Alan Wong3, and Julien Valette1,2
1Molecular Imaging Research Centre (MIRCen), Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Fontenay-aux-Roses, France, 2UMR 9199, Neurodegenerative Diseases Laboratory, Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud, Université Paris-Saclay, Fontenay-aux-Roses, France, 3NIMBE/ Laboratoire de Structure et Dynamique par Résonance Magnétique (LSDRM), Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Gif-sur-Yvette, France

Diffusion in the extracellular space is assessed by state-of-the-art diffusion-weighted MRS techniques following intracerebral injection of sucrose, which predominantly remains in the extracellular space. Sucrose diffusion appears to be not strictly Gaussian and different from intracellular metabolites diffusion. Signal attenuation is stronger and deviates from mono-exponential attenuation at very high b-values, suggesting the presence of some highly restricted pool. The ADC is higher and decreases when augmenting td, indicating that the tortuosity regime is not reached yet. Lastly, unlike intracellular metabolites, sucrose diffusion does not exhibit microstructural anisotropy in double-diffusion-encoding experiments.

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