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Abstract #0853

Myelin weighted tractography: a new way to investigate bundles myelination in-vivo?

Simona Schiavi1,2, Po-Jui Lu3,4, Matthias Weigel3,4,5, Derek K. Jones6,7,8, Ludwig Kappos3,4, Cristina Granziera3,4, and Alessandro Daducci1
1Department of Computer Science, University of Verona, Verona, Italy, 2DINOGMI, University of Genoa, Genoa, Italy, 3Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, 4Translational Imaging in Neurology (ThINk) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, 5Radiological Physics, Department of Radiology, University Hospital Basel and University of Basel, Basel, Switzerland, 6Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom, 7Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom, 8Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia

Tractometry is a widely used tool to investigate microstructural properties that reflect differences in white matter tracts. It consists in averaging tissue features (obtained from any voxel-wise map) along streamlines recovered with diffusion tractography. To overcome the bias introduced by the average, we propose a new method to deconvolve on each individual tract the actual value measured by the microstructural map. For the first time we were able to assess the bundle-specific myelin content by combining tractography with two myelin-sensitive sequences and we obtained good agreement with previously reported values on the cortex.

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