Abstract #0853

Myelin weighted tractography: a new way to investigate bundles myelination in-vivo?

Simona Schiavi^1,2, Po-Jui Lu^3,4, Matthias Weigel^3,4,5, Derek K. Jones^6,7,8, Ludwig Kappos^3,4, Cristina Granziera^3,4, and Alessandro Daducci¹

¹Department of Computer Science, University of Verona, Verona, Italy, ²DINOGMI, University of Genoa, Genoa, Italy, ³Departments of Medicine, Clinical Research and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, ⁴Translational Imaging in Neurology (ThINk) Basel, Department of Medicine and Biomedical Engineering, University Hospital Basel and University of Basel, Basel, Switzerland, ⁵Radiological Physics, Department of Radiology, University Hospital Basel and University of Basel, Basel, Switzerland, ⁶Cardiff University Brain Research Imaging Centre, Cardiff University, Cardiff, United Kingdom, ⁷Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, United Kingdom, ⁸Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, Australia

Tractometry is a widely used tool to investigate microstructural properties that reflect differences in white matter tracts. It consists in averaging tissue features (obtained from any voxel-wise map) along streamlines recovered with diffusion tractography. To overcome the bias introduced by the average, we propose a new method to deconvolve on each individual tract the actual value measured by the microstructural map. For the first time we were able to assess the bundle-specific myelin content by combining tractography with two myelin-sensitive sequences and we obtained good agreement with previously reported values on the cortex.

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