White-matter pathologies disrupt the white-matter organization, that manifests as deficits in brain function. When treating such pathologies, it is of great importance to infer which pathways are affected. However, the white-matter lesions hamper the use of tractography to track fiber bundles. In this work, leveraging diffusion imaging, we propose a novel diffusion-driven technique to improve the localization of brain pathways. Aggregating information from few healthy subjects, our technique is able to localize both the affected pathways and the lesion interrupting when tracking is not possible.