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Abstract #0859

Lesion-Robust White-Matter Bundle Identification through Diffusion Driven Label Fusion

Guillermo Gallardo1, Gaston Zanitti2, Samuel Deslauriers-Gauthier3, Matthew Higger4, Sylvain Bouix4, Alfred Anwander5, and Demian Wassermann2
1Neuropsycology, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Parietal, Inria Saclay - Ile de France, PAris, France, 3Athena EPI, Universite Cote d’Azur, Inria, Sophia Antipolis, France, 4Psychiatry Neuroimaging Laboratory, Brigham and Womens Hospital, Harvard Medical School, Boston, MA, United States, 5Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

White-matter pathologies disrupt the white-matter organization, that manifests as deficits in brain function. When treating such pathologies, it is of great importance to infer which pathways are affected. However, the white-matter lesions hamper the use of tractography to track fiber bundles. In this work, leveraging diffusion imaging, we propose a novel diffusion-driven technique to improve the localization of brain pathways. Aggregating information from few healthy subjects, our technique is able to localize both the affected pathways and the lesion interrupting when tracking is not possible.

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