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Abstract #0860

Investigation of potential effects of sleep on diffusion characteristics of metabolites and water: initial results

André Döring1, Christian Rummel2, Sandra C. Röthlisberger3, Simone Duss3, Corinne Roth3, Claudio Bassetti3,4, and Roland Kreis1
1Depts. Radiology and Biomedical Research, University of Bern, Bern, Switzerland, 2Support Center for Advanced Neuroimaging, University Institute for Diagnostic and Interventional Neuroradiology, Bern, Switzerland, 3Sleep-Wake-Epilepsy-Center, University Hospital Bern, Bern, Switzerland, 4Dept. of Neurology, University Hospital Inselspital Bern, Bern, Switzerland

Diffusion-weighted MR spectroscopy (DW-MRS) and imaging (DW-MRI) was applied to investigate potential effects of sleep on apparent diffusion coefficients (ADCs) of water and metabolites in human gray matter in 7 healthy subjects. Monitoring the transition from wake to sleep for a period of 4 hours did not reveal any significant alterations, while comparison of night measurements after slight sleep deprivation to morning examinations after a full night’s sleep indicated that ADCs for some metabolites are lower in the morning than before sleep – though these results need corroboration in a larger cohort.

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