Abstract #0860

Investigation of potential effects of sleep on diffusion characteristics of metabolites and water: initial results

André Döring¹, Christian Rummel², Sandra C. Röthlisberger³, Simone Duss³, Corinne Roth³, Claudio Bassetti^3,4, and Roland Kreis¹

¹Depts. Radiology and Biomedical Research, University of Bern, Bern, Switzerland, ²Support Center for Advanced Neuroimaging, University Institute for Diagnostic and Interventional Neuroradiology, Bern, Switzerland, ³Sleep-Wake-Epilepsy-Center, University Hospital Bern, Bern, Switzerland, ⁴Dept. of Neurology, University Hospital Inselspital Bern, Bern, Switzerland

Diffusion-weighted MR spectroscopy (DW-MRS) and imaging (DW-MRI) was applied to investigate potential effects of sleep on apparent diffusion coefficients (ADCs) of water and metabolites in human gray matter in 7 healthy subjects. Monitoring the transition from wake to sleep for a period of 4 hours did not reveal any significant alterations, while comparison of night measurements after slight sleep deprivation to morning examinations after a full night’s sleep indicated that ADCs for some metabolites are lower in the morning than before sleep – though these results need corroboration in a larger cohort.

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