Abstract #0876

Three-dimensional MRF obtains highly repeatable and reproducible multi-parametric estimations in the healthy human brain at 1.5T and 3T

Guido Buonincontri^1,2, Jan W Kurzawski^2,3, Joshua Kaggie⁴, Tomasz Matys⁴, Ferdia Gallagher⁴, Matteo Cencini^2,5, Graziella Donatelli^2,6, Paolo Cecchi⁶, Mirco Cosottini^2,6,7, Nicola Martini⁸, Francesca Frijia⁹, Domenico Montanaro⁹, Pedro A Gómez^2,10, Rolf F Schulte¹¹, Alessandra Retico³, and Michela Tosetti^1,2

¹IRCCS Stella Maris, Pisa, Italy, ²Imago7 Foundation, Pisa, Italy, ³Istituto Nazionale di Fisica Nucleare, Pisa, Italy, ⁴Department of Radiology, University of Cambridge, Cambridge, United Kingdom, ⁵University of Pisa, Department of Physics, Pisa, Italy, ⁶U.O. Neuroradiologia, Azienda Ospedaliera Universitaria Pisana (AOUP), Pisa, Italy, ⁷University of Pisa, Department of Translational Research and New Technologies in Medicine and Surgery, Pisa, Italy, ⁸Fondazione Toscana Gabriele Monasterio, Pisa, Italy, ⁹U.O.C. Risonanza Magnetica Specialistica e Neuroradiologia, Fondazione CNR/Regione Toscana G. Monasterio, Pisa, Italy, ¹⁰Technical University of Munich, Munich, Germany, ¹¹GE Healthcare, Munich, Germany

Three-dimensional magnetic resonance fingerprinting with spiral projection k-space trajectory offers fully-quantitative estimations at a high spatial resolution. To assess the repeatability and reproducibility of the estimations, we acquired test/re-test data in the human brain at 1.5T and 3.0T in a travelling head study involving a total of 12 subjects and 8 different MR scanners. Our approach estimated voxel-wise performance in the CNS: variability was assessed using coefficients-of-variation, bias using a GLM analysis. Solid matter repeatability CVs were under 2% for nPD/T1, and 5% for T2, while reproducibility biases were under 10% in solid matter compartments for T1/T2.

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