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Abstract #0877

Fast Simultaneous T1, T2 and T2* Mapping at High Spatial Resolution using 3D Echo-planar Time-resolved Imaging (3D-EPTI)

Fuyixue Wang1,2, Zijing Dong1,3, Timothy G. Reese1, Lawrence L. Wald1,2, and Kawin Setsompop1,2
1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States, 33Department of Electrical Engineering and Computer Science, MIT, Cambridge, MA, United States

An efficient quantitative mapping sequence based on 3D Echo-Planar Time-resolved Imaging (3D-EPTI) is proposed. The acquisition contains inversion recovery gradient echo readouts follow by GRASE-like readouts to provide sensitivity to T1, T2 and T2*. Fast k-TI-TE coverage is achieved by fusing highly-accelerated spatiotemporal CAIPI sampling with golden-angle radial-blade Cartesian under-sampling, where the reconstruction is performed using the subspace model. We demonstrate the high-efficiency of the proposed technique by obtaining multi-contrast images and quantitative maps at 1-mm isotropic resolution whole-brain in 3 minutes.

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