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Abstract #0878

Motion-Resolved, 3D Whole-Brain Simultaneous T1, T2, and T1ρ Mapping using Multitasking with Application to Multiple Sclerosis: A Pilot Study

Sen Ma1,2, Anthony G. Christodoulou2, Nan Wang1,2, Marwa Kaisey3, Nancy L. Sicotte3, and Debiao Li1,2
1Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 2Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 3Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Quantitative multi-parametric relaxometry MRI (e.g., T1, T2, and T1ρ mapping) can demonstrate longitudinal brain changes and enhance lesion contrasts against normal appearing matters in multiple sclerosis. Conventional methods that quantify these relaxation parameters are time-consuming and subject to motion, thus challenging for clinical practice. We present a novel approach that simultaneously quantifies T1, T2, and T1ρ with whole brain coverage in 9min, using the recently developed Multitasking framework that models the multidimensional image as a low-rank tensor. This technique is validated on healthy volunteers. We also demonstrate the feasibility of lesion characterization on relapsing remitting multiple sclerosis patients.

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