Abstract #0878

Motion-Resolved, 3D Whole-Brain Simultaneous T1, T2, and T1ρ Mapping using Multitasking with Application to Multiple Sclerosis: A Pilot Study

Sen Ma^1,2, Anthony G. Christodoulou², Nan Wang^1,2, Marwa Kaisey³, Nancy L. Sicotte³, and Debiao Li^1,2

¹Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ²Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ³Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Quantitative multi-parametric relaxometry MRI (e.g., T1, T2, and T1ρ mapping) can demonstrate longitudinal brain changes and enhance lesion contrasts against normal appearing matters in multiple sclerosis. Conventional methods that quantify these relaxation parameters are time-consuming and subject to motion, thus challenging for clinical practice. We present a novel approach that simultaneously quantifies T1, T2, and T1ρ with whole brain coverage in 9min, using the recently developed Multitasking framework that models the multidimensional image as a low-rank tensor. This technique is validated on healthy volunteers. We also demonstrate the feasibility of lesion characterization on relapsing remitting multiple sclerosis patients.

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