Abstract #0879

Free-Breathing Simultaneous Quantification of Liver T1, Fat and R2* with Variable Flip Angle Golden-Angle-Ordered 3D Stack-of-Radial MRI

Le Zhang¹, Shu-Fu Shih^1,2, Tess Armstrong^1,3, and Holden H. Wu^1,2,3

¹Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, ²Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, ³Physics and Biology in Medicine, University of California, Los Angeles, Los Angeles, CA, United States

Quantification of T₁, proton-density fat fraction (PDFF), and R₂* in the liver can provide information about a range of diseases. Existing Cartesian acquisition schemes generally require breath-holding, which limits spatial coverage and may be difficult for sick, elderly or pediatric patients. In this study, we propose a variable-flip-angle (VFA) golden-angle-ordered (GA) 3D stack-of-radial sequence that can provide multiparametric mapping with volumetric liver coverage in three minutes during free-breathing and with intrinsic motion compensation capability. Pilot studies in healthy subjects demonstrate agreement with reference breath-held scans and good measurement repeatability.

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