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Abstract #0879

Free-Breathing Simultaneous Quantification of Liver T1, Fat and R2* with Variable Flip Angle Golden-Angle-Ordered 3D Stack-of-Radial MRI

Le Zhang1, Shu-Fu Shih1,2, Tess Armstrong1,3, and Holden H. Wu1,2,3
1Radiological Sciences, University of California, Los Angeles, Los Angeles, CA, United States, 2Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States, 3Physics and Biology in Medicine, University of California, Los Angeles, Los Angeles, CA, United States

Quantification of T1, proton-density fat fraction (PDFF), and R2* in the liver can provide information about a range of diseases. Existing Cartesian acquisition schemes generally require breath-holding, which limits spatial coverage and may be difficult for sick, elderly or pediatric patients. In this study, we propose a variable-flip-angle (VFA) golden-angle-ordered (GA) 3D stack-of-radial sequence that can provide multiparametric mapping with volumetric liver coverage in three minutes during free-breathing and with intrinsic motion compensation capability. Pilot studies in healthy subjects demonstrate agreement with reference breath-held scans and good measurement repeatability.

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