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Abstract #0893

7T in-vivo human T2* mapping at 350μm isotropic resolution using ME-GRE with flow artifact mitigation reveals cortical layers & vessels

Omer Faruk Gulban1, Benedikt Poser1, Martin Havlicek1, Federico De Martino1, and Dimo Ivanov1
1Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands

Spatial misencoding of the vascular signal due to flow is an imaging artifact that presents a significant challenge for in vivo MRI at high resolutions (≤0.5mm). Here we propose a method for mitigating this artifact in multi-echo gradient recalled echo (ME-GRE) images at 350μm isotropic resolution by applying 90° rotations to their phase-encoding direction. After applying our method, we demonstrate clearly visible stria of Gennari, intracortical veins, and pial vessels while mitigating the flow artifact. In addition, we report T2* estimates of several human brain tissues (artery, vein, gray/white matter, CSF) in-vivo which are valuable for future hemodynamic signal modeling.

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