Quantitative MRI is of great value to both clinical diagnosis and scientific research. In this study, a novel T2* mapping method, gradient-echo multiple overlapping-echo detachment acquisition (GRE-MOLED) sequence with deep learning-based reconstruction algorithm was proposed. The method is capable of acquiring reliable T2*, M0 and B0 maps simultaneously in a single shot and is robust to B0-inhomogeneities. As a rapid T2* quantitative tool, GRE-MOLED reduces the scan time of T2* mapping to less than 75 ms per slice and has great potential in clinical real-time applications.
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