Abstract #0895

Dual Flip-angle IR-FLASH for B1+ Insensitive T1 Mapping: Application to T1 CMR Multitasking.

Fardad Michael Serry¹, Sen Ma^1,2, Debiao Li^1,2, and Anthony G Christodoulou¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA, United States

T1 mapping is important for many diseases, from cancer [1] to cardiovascular disease [2], and more. Many fast T1 mapping protocols rely on an IR-FLASH sequence, especially in the heart. However, the accuracy and repeatability of T1 mapping with IR-FLASH are compromised by B1+ inhomogeneity. Here we present a simple dual-flip-angle (DFA) modification of the IR-FLASH pulse sequence to provide B1+-robust T1 mapping that obviates the need for a separate B1+ scan . We show the improved agreement of DFA-IR-FLASH to IR-TSE in a phantom study as well as its feasibility for in vivo cardiac T1 mapping with MR Multitasking.

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