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Abstract #0896

Simultaneous measurements of blood flow and blood water T2: a general-purpose sequence for T2-based measurement of whole-organ O2 consumption

Cheng-Chieh Cheng1, Pei-Hsin Wu1, Michael C. Langham1, and Felix W. Wehrli1
1University of Pennsylvania, Philadelphia, PA, United States

A T2-based oximetry method for quantifying whole-organ metabolic rate of oxygen (MRO2): A velocity-encoded acquisition module with golden-angle radial sampling was inserted into a background-suppressed T2-prepared sequence specifically for blood water T2 quantification. Parallel imaging and compressed-sensing techniques were applied to the reconstruction of the sparsely-sampled velocity-encoded k-space data to generate velocity maps. Whole-organ oxygen metabolic rate was estimated by converting T2 to blood oxygenation level via a calibration curve. A pilot study in the superior sagittal sinus showed the method’s ability to estimate whole-brain CMRO2 (136±23 μmol/minute/100g, mean±S.D.) in a single pass.

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