We report here in vivo 50-micron cerebral blood volume (CBV) mapping of the mouse brain using intraperitoneal injection protocol of gadolinium-based contrast agent. Based on k-means clustering we identified different vascular clusters that separately range from macro- to micro-vasculature. The CBV map demonstrated layer-dependent macro- and micro-vascular densities in the cortex where different cortical regions exhibited different vascular patterns. The CBV map also identified different vascular densities and patterns in the hippocampus. These results suggest that CBV map would be a useful and alternative tool that assesses brain function and metabolism at extremely high spatial resolution.
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