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Abstract #0897

Toward high spatial resolution functional MRI: In vivo 50-micron cerebral blood volume mapping of the mouse brain

Akira Sumiyoshi1, Keigo Hikishima2, and Ichio Aoki1
1National Institutes for Quantum and Radiological Science and Technology (QST), Chiba, Japan, 2Okinawa Institute of Science and Technology Graduate University (OIST), Okinawa, Japan

We report here in vivo 50-micron cerebral blood volume (CBV) mapping of the mouse brain using intraperitoneal injection protocol of gadolinium-based contrast agent. Based on k-means clustering we identified different vascular clusters that separately range from macro- to micro-vasculature. The CBV map demonstrated layer-dependent macro- and micro-vascular densities in the cortex where different cortical regions exhibited different vascular patterns. The CBV map also identified different vascular densities and patterns in the hippocampus. These results suggest that CBV map would be a useful and alternative tool that assesses brain function and metabolism at extremely high spatial resolution.

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