Abstract #0900

Multi-tissue constrained spherical deconvolution in a murine brain

Steven Jillings¹, Jan Morez², Nicholas Vidas-Guscic³, Johan Van Audekerke³, Floris Wuyts¹, Marleen Verhoye³, Jan Sijbers², and Ben Jeurissen²

¹Lab for Equilibrium Investigations and Aerospace, Dept. of Physics, University of Antwerp, Antwerp, Belgium, ²imec-Vision Lab, Dept. of Physics, University of Antwerp, Antwerp, Belgium, ³Bio Imaging Lab, Dept. of Biomedical Sciences, University of Antwerp, Antwerp, Belgium

Multi-tissue constrained spherical deconvolution (MT-CSD) leverages the unique b-value dependency of each brain tissue type to estimate the full white matter (WM) fiber orientation density function (fODF) as well as the apparent densities of gray matter (GM) and cerebrospinal fluid (CSF), directly from multi-shell diffusion MRI (dMRI) data. Currently, its adoption is focussed almost entirely on imaging of the human brain. In this work, we demonstrate that the sequence, the pipeline and the advantages that are now well established for human brains, can be transferred to murine brains, bringing the technique into the preclinical realm.

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