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Abstract #0901

3D Magnetic Resonance Fingerprinting with Quadratic Phase in Mouse Brain on Preclinical 7T System

Charlie Wang1, Yuning Gu2, Rasim Boyacioglu2, Charlie Androjna3, Mark Alan Griswold2, and Xin Yu2
1Metrohealth Hospital, Cleveland, OH, United States, 2Case Western Reserve University, Cleveland, OH, United States, 3Cleveland Clinic, Cleveland, OH, United States

Magnetic Resonance Fingerprinting with Quadratic Phase (qRF-MRF) was previously validated in 2D clinical imaging for simultaneous off-resonance, T1, T2, and T2* mapping. Translation of qRF-MRF to high-field preclinical systems for small animal imaging is challenging due to the higher field inhomogeneity and the higher spatial resolution required. Here, a 3D qRF-MRF method was explored to address these challenges. High-resolution simultaneous mapping of off-resonance, T1, T2, and T2* on in vivo mouse brain at 7T was demonstrated. Computational limitations for large dictionary parameter space and reconstruction times were addressed using randomized SVD time compression and quadratic fitting methods.

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