While glycosaminoglycan deposition in Mucopolysaccharidosis type II, a rare X-linked lysosomal storage disorder, unquestionably alters the brain, metabolic and microstructural MR markers have not been yet established. Thus, we utilized 3T diffusion MRI and fine-tuned semi-LASER MR spectroscopy as well as in-house developed 7T 3D-FID-MRS imaging to examine differences between seven MPSII and eight age-matched healthy males. Analyses revealed profound deficit in the supratentorial white matter consistent with de/dysmyelination on both diffusion and spectroscopy as well as decrease of neuronal population or hypometabolism measured as glutamate deficit in the posterior cingulate cortex, which is a critical hub of neurocognitive networks.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords