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Abstract #0915

Neurocognitive and psychiatric features among primary Sjögren’s syndrome patients: from clinical outcomes to brain MRI

Radjiv Goulabchand1,2,3, Veronica Ravano4,5,6, Mário João Fartaria4,5,6, Ricardo Corredor-Jerez4,5,6, Elodie Castille1,3, Sophie Navucet7, Alexandre Maria1,2,8, Alain Le Quellec1,2, Emmanuelle Le Bars9,10,11, Audrey Gabelle2,7,12, Philippe Guilpain1,3,8, Nicolas Menjot de Champfleur9,10, and Bénédicte Maréchal4,5,6
1Département de médecine interne et maladies multi-organiques, Hôpital Saint Eloi, CHRU Montpellier, Montpellier, France, 2Médecine interne, CHU de Nîmes, Nîmes, France, 3Faculté de médecine, Université de Montpellier, Montpellier, France, 4Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, 5Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, 6LTS 5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, 7Centre Mémoire de Ressources et de Recherche, Hôpital Gui De Chauliac, CHRU Montpellier, Montpellier, France, 8IRMB, INSERM, CHU Montpellier, Montpellier, France, 9Département d’imagerie médicale, Hôpital Gui de Chauliac, CHRU Montpellier, Montpellier, France, 10Institut d'Imagerie Fonctionnelle Humaine (I2FH), Hôpital Gui de Chauliac, Centre Hospitalier Régional Universitaire de Montpellier, Montpellier, France, 11Laboratoire Charles Coulomb, CNRS UMR 5221, Université de Montpellier, Montpellier, France, 12Laboratoire de Biochimie-Protéomique Clinique - IRMB - CCBHM - Inserm U1183, CHU Montpellier, Hôpital St-Eloi - Université Montpellier, Montpellier, France

To date, neuropsychiatric profiles in Sjögren’s syndrome patients are not explained by the immunological profile or clinical symptoms. Consequently, there is a lack of biomarkers potentially characterizing such profiles for this rare autoimmune disease. Our goal was to investigate the potential of MRI-based features to objectively explain fatigue, depression and cognitive complaints in twenty-nine patients with primary Sjögren’s syndrome. Specifically, we explored features from automated brain morphometry and brain lesion segmentation as potential imaging biomarkers. Z-score differences in certain brain structures (thalamus, corpus callosum, ventricles, and insula) were found, suggesting an association between MRI-based biomarkers and patient’s neuropsychiatric profiles.

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