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Abstract #0923

Repercussions of a single concussion in the mouse brain: insights from functional and structural Magnetic Resonance Imaging.

Xuan Vinh To1 and Fatima A. Nasrallah1,2
1The Queensland Brain Institute, The University of Queensland, Australia, Queensland, Australia, 2The Centre for Advanced Imaging, The University of Queensland, Australia, St Lucia, Australia

Resting-state functional connectivity in mouse model of concussion detected a process of functional adaptation at day 2 post-injury in compensation for white matter injuries: increased connectivity among the Default Mode and Hippocampal Networks and decreased or negative connectivity to the Midbrain. These adaptations maintained cognition and spatial learning but negatively affected the motor and balance functions. The functional adaptations were short-term: at day 7, increased cellularity were detected by Diffusion MRI in grey matter regions involved with day 2 functional adaptations.

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