Diffusion tensor and propagator metrics are compared directly in post-mortem cortex specimens from humans with chronic traumatic encephalopathy. Significant correlation was found between fractional anisotropy and non-Gaussianity with pTau staining in the sulcal depths. Additionally, GFAP staining of astrocytosis in the white matter was significantly correlated with Trace, FA, return-to-origin probability and propagator anisotropy. Cluster-based methods were also applied to explore the multivariate diffusion signature associated with CTE pathology. These findings suggest that diffusion metrics may be sensitive to CTE-related pathology.