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Abstract #0924

Correspondence of diffusion tensor and propagator metrics with quantitative histologic outcomes in chronic traumatic encephalopathy        

Mihika Gangolli1, Elizabeth Hutchinson2, Ann McKee3, Joong Hee Kim1, Sinisa Pajevic1, and Peter Basser1
1National Institutes of Health, Bethesda, MD, United States, 2BME, University of Arizona, Tucson, AZ, United States, 3Boston University, Boston, MA, United States

Diffusion tensor and propagator metrics are compared directly in post-mortem cortex specimens from humans with chronic traumatic encephalopathy. Significant correlation was found between fractional anisotropy and non-Gaussianity with pTau staining in the sulcal depths. Additionally, GFAP staining of astrocytosis in the white matter was significantly correlated with Trace, FA, return-to-origin probability and propagator anisotropy. Cluster-based methods were also applied to explore the multivariate diffusion signature associated with CTE pathology. These findings suggest that diffusion metrics may be sensitive to CTE-related pathology.

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