Abstract #0931

White matter microstructure characterisation in left and right temporal lobe epilepsy (TLE) using TBSS

Nicolò Rolandi¹, Fulvia Palesi¹, Francesco Padelli², Isabella Giachetti², Domenico Aquino², Giuseppe Didato³, Elio Maccagnano³, Paul Summers⁴, Giancarlo Germani⁴, Claudia AM Gandini Wheeler-Kingshott^1,5,6, and Paolo Vitali⁴

¹Department of Brain and Behavioral Science, University of Pavia, Pavia, Italy, ²Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Milan, Italy, ³Neuroradiology, Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta, Milan, Italy, ⁴Neuroradiology Unit, Brain MRI 3T Research Center, IRCCS Mondino Foundation, Pavia, Italy, ⁵Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, NMR Research Unit, Queen Square MS Centre, London, United Kingdom, ⁶Brain MRI 3T Research Center, IRCCS Mondino Foundation, Pavia, Italy

Tract-based spatial statistics investigations of temporal lobe epilepsy (TLE) have been using standard diffusion metrics, without distinguishing patients according to the lateralization of their epileptogenic zone. The aim of this study is to further our knowledge by identifying specific patterns of alteration in left and right TLE patients using diffusion kurtosis imaging and NODDI parameter maps. Our findings demonstrate the presence of specific patterns of white matter alterations, with the left TLE more widely affecting both cerebral and cerebellar regions. These results support the need to consider patients separately, according to the side of their pathology.

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