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Abstract #0932

Visualization enhancement and quantitative analysis of relaxation time in medial temporal lobe epilepsy based on 3D high-resolution MRF

Xiaozhi Cao1,2,3, Kang Wang4, Congyu Liao2,3, Dengchang Wu4, Qing Li1, Ziyang Chen1, Jun Li1, Huihui Ye1, Hongjian He1, and Jianhui Zhong1
1Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, 2Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, charlestown, MA, United States, 3Department of Radiology, Harvard Medical School, charlestown, MA, United States, 4Department of Neurology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

We propose to use a 3D MRF technique with multi-axis spiral projection acquisition to achieve 3D high-resolution whole-brain quantitative imaging for patients with MTLE. Isotropic 1-mm resolution relaxivity maps were achieved within 5 minutes. By incorporating Freesurfer’s automatic subcortical segmentation, a whole-brain subcortical segmentation was obtained, enabling feasible and subjective quantitative analysis for each substructure. Additionally, volume information of the substructure was obtained during the process.

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