Abstract #0932

Visualization enhancement and quantitative analysis of relaxation time in medial temporal lobe epilepsy based on 3D high-resolution MRF

Xiaozhi Cao^1,2,3, Kang Wang⁴, Congyu Liao^2,3, Dengchang Wu⁴, Qing Li¹, Ziyang Chen¹, Jun Li¹, Huihui Ye¹, Hongjian He¹, and Jianhui Zhong¹

¹Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, charlestown, MA, United States, ³Department of Radiology, Harvard Medical School, charlestown, MA, United States, ⁴Department of Neurology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China

We propose to use a 3D MRF technique with multi-axis spiral projection acquisition to achieve 3D high-resolution whole-brain quantitative imaging for patients with MTLE. Isotropic 1-mm resolution relaxivity maps were achieved within 5 minutes. By incorporating Freesurfer’s automatic subcortical segmentation, a whole-brain subcortical segmentation was obtained, enabling feasible and subjective quantitative analysis for each substructure. Additionally, volume information of the substructure was obtained during the process.

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