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Abstract #0933

CORTICAL THICKNESS COVARIANCE STRUCTURAL NETWORKS IN “FOCAL” EPILEPSY 

Karthik Kulanthaivelu1, Kiran Raj V1, Raghavendra Kenchaiah 2, Jitender Saini1, Rose Dawn Bharath1, and Sanjib Sinha2
1Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Bengaluru, India, 2Department of Neurology, National Institute of Mental Health and Neurosciences, Bengaluru, India

“Focal” epilepsy is a network aberration. Network characteristics in focal epilepsy due to calcified Neurocysticercal granuloma have not been elucidated. Forty-two patients of focal epilepsy with MRI evidence of either calcified granuloma, malformation of cortical development, mesial temporal sclerosis, or no imaging abnormality were included. Group-level Cortical thickness covariance networks were generated and compared. Focal epilepsy patients (including those with calcific granuloma) had significantly reduced network global efficiency and higher nodal characteristic path length/ Clustering coefficient/ Nodal local efficiency (p<0.05). Networks in focal epilepsy (“ including those due to calcific granuloma”) have higher segregation and lesser integration.

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