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Abstract #0935

Using High-resolution 3D MR Fingerprinting for Characterization of Focal Cortical Dysplasia

Joon Yul Choi1, Rasim Boyacioglu2, Stephen Jones3, Ken Sakaie3, Ingmar Bl├╝mcke1,4, Imad Najm1, Mark Griswold2, Dan Ma5, and Zhong Irene Wang1
1Epilepsy Center / Neurological Institute, Cleveland Clinic, Cleveland, OH, United States, 2Radiology, Case Western Reserve University, Cleveland, OH, United States, 3Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 4Neuropathology, University of Erlangen, Erlangen, Germany, 5Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

We investigate in this study quantitative T1 and T2 values as potential biomarkers of tissue properties in epilepsy patients with focal cortical dysplasia (FCD) using a novel high-resolution 3D magnetic resonance fingerprinting (MRF) technique. We first investigated the quantitative T1 and T2 values in various Brodmann areas to verify the sensitivity of MRF in probing tissue properties of the human cortex. We then investigated the MRF T1 and T2 values in different subtypes of FCD lesions, which were higher than their corresponding cortical regions in the controls.

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