Abstract #0935

Using High-resolution 3D MR Fingerprinting for Characterization of Focal Cortical Dysplasia

Joon Yul Choi¹, Rasim Boyacioglu², Stephen Jones³, Ken Sakaie³, Ingmar Blümcke^1,4, Imad Najm¹, Mark Griswold², Dan Ma⁵, and Zhong Irene Wang¹

¹Epilepsy Center / Neurological Institute, Cleveland Clinic, Cleveland, OH, United States, ²Radiology, Case Western Reserve University, Cleveland, OH, United States, ³Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, ⁴Neuropathology, University of Erlangen, Erlangen, Germany, ⁵Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States

We investigate in this study quantitative T1 and T2 values as potential biomarkers of tissue properties in epilepsy patients with focal cortical dysplasia (FCD) using a novel high-resolution 3D magnetic resonance fingerprinting (MRF) technique. We first investigated the quantitative T1 and T2 values in various Brodmann areas to verify the sensitivity of MRF in probing tissue properties of the human cortex. We then investigated the MRF T1 and T2 values in different subtypes of FCD lesions, which were higher than their corresponding cortical regions in the controls.

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