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Abstract #0936

Resting-state functional connectivity alterations in periventricular nodular heterotopia related epilepsy

Xinyu Hu1, Wenyu Liu2, Dong Zhou2, Qiyong Gong1, and Xiaoqi Huang1
1Huaxi MR Research Center (HMRRC), West China Hospital of Sichuan University, Chengdu, China, 2Department of Neurology, West China Hospital of Sichuan University, Chengdu, China

We performed the first resting-state fMRI study integrating both whole-brain functional connectivity (FC) and seed-based FC analyses to explore the network-level neural function alterations in patients with periventricular nodular heterotopia (PNH). Our findings (i) identified lower functional connectivity strength (FCS, an index of whole-brain connectivity) in bilateral insula, higher FC in the precuneus and lower FC in the anterior cingulate cortex/medial prefrontal cortex and cerebellum networks in PNH patients and (ii) demonstrated that the significant insular hypoactivation represented the cortical hub of the whole-brain networks in PNH, which might be of clinical significance in predicting disability progression of PNH.

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