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Abstract #0937

Quantifying Hippocampal Dentation in Epilepsy: a comparison of absolute mean curvature versus visual inspection and their memory correlates.

Lawrence Ver Hoef1,2, Mike Zhang3, and Anandh Kilpattu Ramaniharan3
1Neurology, University of Alabama at Birmingham, Birmingham, AL, United States, 2Birmingham VA Medical Center, Birmingham, AL, United States, 3University of Alabama at Birmingham, Birmingham, AL, United States

Hippocampal dentation (HD) is a morphologic feature of the human hippocampus that has been recently described and has been shown to correlate with aspects of verbal and visual memory. It varies dramatically across healthy individuals and can be affected by diseases such as epilepsy. We demonstrate a method to extract ultra-high-resolution surface contours from common MPRAGE images. We also propose a method based on absolute mean curvature to quantify HD and compare that to visual inspection in a cohort of temporal lobe epilepsy patients. Finally, we examine correlations between HD and measures of verbal and visual memory across methods.

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