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Abstract #0938

Quantitative susceptibility mapping reveals abnormal zinc, calcium and iron levels in focal cortical dysplasia lesions

Sara Lorio1, Po-Wah So1, Jan Sedlacik1, Derek Li2, Emma Dixon3, Sophie Adler3, Harold G. Parkers1, Helen J. Cross3, Torsten Baldeweg3, Thomas Jacques3, Karin Shmueli3, and David Carmichael1,3
1King's College London, London, United Kingdom, 2UCL, London, United Kingdom, 3UCL, LONDON, United Kingdom

We estimated quantitative susceptibility maps (QSM) in 19 children with histologically confirmed focal cortical dysplasia (FCD), a frequent cause of drug-resistant epilepsy. QSM allowed measurement of cortical and sub-cortical layered structure and its alteration in FCD lesions. Moreover, QSM was sensitive to abnormal deposits of calcium, zinc, and iron, which were validated using X-ray fluorescence in brain tissue specimens available following surgical treatment. QSM could provide a non-invasive biomarker of cortical tissue changes in epilepsy and could be used to determine alterations in mineral deposits in different brain disorders.

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