Focal cortical dysplasia (FCD) are neurodevelopmental disorders characterized by localized cortical malformation that is highly associated with the drug-resistant epilepsy. In this study, we examined the advanced diffusion MR imaging-neurite orientation dispersion and density imaging (NODDI) in the FCD mice model. The orientation dispersion index (ODI) that represents the dispersion of neurite is significantly higher in the FCD group compared with the control group which are compatible with the pathological observation. Meanwhile, no significant differences are observed in conventional DTI measurements FA and MD indicating that NODDI is more sensitive in detecting FCD lesion.
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