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Abstract #0939

Assessing Focal Cortical Dysplasia Using Advanced Diffusion Imaging Sequences

Boyu Zhang1, Shaoping Zhong2, Yuwen Zhang1, Qianfeng Wang1, Jing Ding2, and He Wang1,3
1Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, 2Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China, 3Human Phenome Institute, Fudan University, Shanghai, China

Focal cortical dysplasia (FCD) are neurodevelopmental disorders characterized by localized cortical malformation that is highly associated with the drug-resistant epilepsy. In this study, we examined the advanced diffusion MR imaging-neurite orientation dispersion and density imaging (NODDI) in the FCD mice model. The orientation dispersion index (ODI) that represents the dispersion of neurite is significantly higher in the FCD group compared with the control group which are compatible with the pathological observation. Meanwhile, no significant differences are observed in conventional DTI measurements FA and MD indicating that NODDI is more sensitive in detecting FCD lesion.

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