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Abstract #0940

Significance of Perivascular Spaces in Acute Ischemic Stroke and its Predictions of Epileptogenesis

Nian Yu1,2,3, Benjamin Sinclair4,5, Lina Maria Garcia Posada6, Ben Chen4, Qing Di1, Xingjian Lin1, Qingling Huang7, Scott Kolbe4, Patrick Kwan2,4,5,8, and Meng Law4,6
1Department of Neurology, The Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China, 2Department of Neurology, Royal Melbourne Hospital, Melbourne, Australia, 3Department of Radiology, The Nanjing Brain Hospital Affiliated to Nanjing Medical University, Melbourne, China, 4Department of Neuroscience, Monash University, Melbourne, Australia, 5Department of Neurology, Alfred Hospital, Melbourne, Australia, 6Department of Radiology, Alfred Hospital, Melbourne, Australia, 7Department of Radiology, The Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China, 8Department of Medicine, University of Melbourne, Melbourne, Australia

Around 10% of patients with stroke go on to develop epilepsy, however, imaging biomarkers for post-stroke epilepsy (PSE) are lacking. Perivascular spaces (PVS) are small interstitial fluid filled spaces lining the blood vessels which have a role in waste clearance in the brain. They have been found to be abnormal in epilepsy, and here we investigate whether they could serve as an early predictor of PSE. We found that the overall number and scores of enlarged PVSs were not associated with PSE, but the inter-hemispheric asymmetry was an independently associated biomarker.

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