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Abstract #0942

MRI Assessment of Renal Tubular Volume Fraction with an IVIM-NNLS Approach Under Increased Tubular Pressure

Joao Santos Periquito1, Kathleen Cantow2, Thomas Gladytz3, Bert Flemming2, Dirk Grosenick3, Erdmann Seeliger2, Thoralf Niendorf1, and Andreas Pohlmann1
1Max Delbrueck Center for Molecular Medicine, Berlin, Germany, 2Institute for Vegetative Physiology, Charité – Universitaetsmedizin Berlin, Berlin, Germany, 3Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany

The measurement of tubular volume fraction changes in the kidney may be valuable as a confounder of T2*-derived tissue oxygenation and as a potential biomarker. Diffusion weighted imaging provides information about in-vivo water mobility which can be linked to three sources: tissue water diffusion, blood perfusion within intrarenal microvasculature, and tubular fluid. In this work we explore the feasibility of assessing tubular volume fraction changes using the non-negative least squares (NNLS) approach under different physiological conditions.

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