Abstract #0942

MRI Assessment of Renal Tubular Volume Fraction with an IVIM-NNLS Approach Under Increased Tubular Pressure

Joao Santos Periquito¹, Kathleen Cantow², Thomas Gladytz³, Bert Flemming², Dirk Grosenick³, Erdmann Seeliger², Thoralf Niendorf¹, and Andreas Pohlmann¹

¹Max Delbrueck Center for Molecular Medicine, Berlin, Germany, ²Institute for Vegetative Physiology, Charité – Universitaetsmedizin Berlin, Berlin, Germany, ³Physikalisch-Technische Bundesanstalt (PTB), Berlin, Germany

The measurement of tubular volume fraction changes in the kidney may be valuable as a confounder of T₂*-derived tissue oxygenation and as a potential biomarker. Diffusion weighted imaging provides information about in-vivo water mobility which can be linked to three sources: tissue water diffusion, blood perfusion within intrarenal microvasculature, and tubular fluid. In this work we explore the feasibility of assessing tubular volume fraction changes using the non-negative least squares (NNLS) approach under different physiological conditions.

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