Abstract #0943

Delayed urea differential enhancement CEST (dudeCEST)-MRI with T1 correction for monitoring renal urea handling

Soo Hyun Shin¹, Brandon Zhang¹, K. L. Barry Fung¹, Michael F. Wendland², and Moriel H. Vandsburger¹

¹Department of Bioengineering, University of California, Berkeley, Berkeley, CA, United States, ²Berkeley Preclinical Imaging Core (BPIC),University of California, Berkeley, Berkeley, CA, United States

Urea recycling is a major component of renal tubular function and may provide an in vivo surrogate for tubular dysfunction in renal diseases. We demonstrate an approach of delayed urea differential enhancement CEST (dudeCEST)-MRI, which detects enhanced urea CEST contrast specific to the inner medulla and papilla of the mouse kidney at 20 minutes after urea injection. To enhance quantification while accounting for different T₁ values within the kidney, apparent exchange-dependent relaxation (AREX) correction was applied. The combination of dudeCEST with AREX analysis will be a useful platform for assessment of renal urea recycling as a surrogate for tubular dysfunction.

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