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Abstract #0943

Delayed urea differential enhancement CEST (dudeCEST)-MRI with T1 correction for monitoring renal urea handling

Soo Hyun Shin1, Brandon Zhang1, K. L. Barry Fung1, Michael F. Wendland2, and Moriel H. Vandsburger1
1Department of Bioengineering, University of California, Berkeley, Berkeley, CA, United States, 2Berkeley Preclinical Imaging Core (BPIC),University of California, Berkeley, Berkeley, CA, United States

Urea recycling is a major component of renal tubular function and may provide an in vivo surrogate for tubular dysfunction in renal diseases. We demonstrate an approach of delayed urea differential enhancement CEST (dudeCEST)-MRI, which detects enhanced urea CEST contrast specific to the inner medulla and papilla of the mouse kidney at 20 minutes after urea injection. To enhance quantification while accounting for different T1 values within the kidney, apparent exchange-dependent relaxation (AREX) correction was applied. The combination of dudeCEST with AREX analysis will be a useful platform for assessment of renal urea recycling as a surrogate for tubular dysfunction.

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