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Abstract #0945

Travelling kidneys: Multicentre multivendor variability of renal diffusion-weighted imaging – preliminary results

Fabio Nery1, Charlotte Buchanan2, Andrew Priest3, João Sousa4, Michael Nation5, Iosif Mendichovszky3, Steven Sourbron6, Susan Francis2, and David Thomas7,8,9
1UCL Great Ormond Street Institute of Child Health, London, United Kingdom, 2Sir Peter Mansfield Imaging Centre, University of Nottingham, University Park, Nottingham, United Kingdom, 3Department of Radiology, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, United Kingdom, 4Imaging Biomarkers Group, Department of Biomedical Imaging Sciences, University of Leeds, Leeds, United Kingdom, 5Kidney Research UK, Peterborough, United Kingdom, 6Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 7Neuroradiological Academic Unit, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 8Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom, 9Wellcome Centre for Human Neuroimaging, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom

Multicentre validation studies are required to enable clinical translation of renal MRI biomarkers. Here, we report on the feasibility of standardising renal diffusion weighting imaging protocols and on the variability of renal apparent diffusion coefficient across a range of vendors. Results suggest feasibility of implementing near-identical renal diffusion weighted imaging acquisition protocols with product sequences and the potential of the apparent diffusion coefficient as a robust metric to characterise renal microstructure in multi-centre studies.

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