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Abstract #0946

Novel magnetic resonance kidney biomarker Parenchyma-T2 for assessment of Autosomal dominant polycystic kidney disease

Florian Siedek1, Franziska Grundmann2, Kilian Weiss1, Daniel Pinto dos Santos1, Sita Arjune2, Stefan Haneder1, Thorsten Persigehl1, Roman-Ulrich Mueller2, and Bettina Baessler1
1Radiology, University of Cologne, Cologne, Germany, 2Department II of Internal Medicine, University of Cologne, Cologne, Germany

Novel biomarkers for a more sensitive and quick assessment of ADPKD patients especially in those cases where kidney function is still preserved and can be maintained is urgently needed. We analyzed in 139 patients and 10 healthy controls if magnetic resonance T2 mapping of the kidneys allows a sufficient differentiation of cyst fraction as a surrogate marker for disease severity. The new biomarker parenchyma-T2 showed the strongest correlation to renal cyst fraction and was faster to determine than the established biomarker htTKV. Consequently, parenchyma-T2 has the potential to serve as a novel predictive biomarker especially in early stages of disease.

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