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Abstract #0947

Diffusional Kurtosis Imaging of kidney in STZ-induced Diabetic Rats.

Youzhen Feng1, Zhongyuan Cheng1, Xiaoqiao Chen2, Xiaoqing Xiong1, Qiting Lin1, Dingkun SiTu1, Long Qian3, Huomei Chen1, and Xiangran Cai1
1Medical Imaging Center, First Affiliated Hospital, Jinan University, Guangzhou, Guangdong, China, Guangzhou, China, 2Medical Imaging Center, The Eighth Hospital of Sun Yat-sen University,shenzhen,China., Shenzhen, China, 3MR Research, GE Healthcare., Beijing, China

Diffusional kurtosis imaging (DKI) is an advanced diffusion model and could identify the heterogeneity of cellularity and microstructural complexity1,2. To test whether the DKI could detect the functional changes of kidney in early Diabetic kidney disease (DKD), the STZ-induced diabetic rats were applied in current study. Further, the biochemical and pathological evidences would also be provided to compare with the DKI biomarker.

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