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Abstract #0950

T2 and diffusion tensor imaging of kidney disease in an epicutaneous TLR7 enhanced lupus mouse model

Luke Xie1, Vineela D. Gandham1, Kai H. Barck1, Eric Suto1, Wyne P. Lee1, Oded Foreman1, Richard A. D. Carano1, Alex J. De Crespigny1, and Robby M. Weimer1
1Genentech, South San Francisco, CA, United States

System lupus erythematosus (SLE) is an autoimmune disease that can lead to lupus nephritis and glomerulonephritis. Studies have evaluated kidneys from SLE patients using diffusion-weighted imaging. However, specific MRI metrics most related to the underlying disease has not been identified. In this study, we evaluate a lupus model with MRI and determine the physical properties that contribute to the MRI signal. This is achieved through structural analysis of glomeruli with whole kidney 3D micro-CT and pathological evaluation of glomeruli, tubules, interstitium, and arterioles. Finally, a comprehensive correlation analysis is performed to determine top MRI metrics most sensitive to the disease.

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