Abstract #0949

Iopamidol CEST MR Urography for Urinary Tract Obstructions

KowsalyaDevi Pavuluri¹, Shaowei Bo¹, Farazad Sedaghat¹, Max Kates², and Michael T McMahon^1,3

¹The Russell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Department of Urology, The Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States

Urinary tract obstructions (UTOs) are impairments in urine flow which can lead to pain, infection and irreversible kidney damage if left undiagnosed or untreated. Chemical exchange saturation transfer (CEST) is a novel MRI contrast mechanism that is particularly sensitive to environmental changes including changes in pH values. In this study we developed a protocol by administering the FDA approved iopamidol to obtain dynamic pH and perfusion MRI contrast maps of the kidneys and compared these with iopamidol administered multi-phase CT in a unilateral urinary obstruction mouse model.

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