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Abstract #0952

Assessment of Acute Kidney Injury and associated longitudinal changes with recovery using multiparametric renal MRI

Charlotte Elizabeth Buchanan1, Huda Mahmoud2, Eleanor F Cox1, Rebecca Noble2, Benjamin L Prestwich1, Isma Kazmi 2, Maarten W Taal2, Nicholas Selby2, and Susan T Francis1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Centre for Kidney Research and Innovation, University of Nottingham, Derby, United Kingdom

Acute kidney injury (AKI) is defined clinically using serum creatinine. We use multiparametric renal MRI to assess longitudinal changes in AKI. Nine participants were assessed at time of AKI, 7 were re-scanned at 3-months and 1-year. At peak AKI, total kidney volume (TKV) and cortex and medulla T1 were elevated, and cortex perfusion reduced compared to HVs. After 3-months, TKV reduced compared to peak AKI, cortex and medulla T1 remained slightly elevated compared to HVs. Perfusion remained reduced compared to HVs after 1-year. MRI showed incomplete recovery at 3 months, despite normalisation of biochemistry, providing potential to identify maladaptive repair.

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