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Abstract #0953

Diffusion-PEPTIDE: rapid distortion-free diffusion-relaxometry imaging

Merlin J Fair1,2, Congyu Liao1,2, Daeun Kim3, Divya Varadarajan1,2, Justin P Haldar3,4, and Kawin Setsompop1,2,5
1A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 2Department of Radiology, Harvard Medical School, Boston, MA, United States, 3Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, 4Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, 5Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States

Diffusion-PEPTIDE incorporates the recently developed rapid multi-shot relaxometry technique Propeller EPTI with Dynamic Encoding (PEPTIDE) into a diffusion acquisition scheme. PEPTIDE enables fast acquisition of distortion- and blurring-free images, time-resolved for different timepoints with varying T2 & T2* weighting, with self-navigation for correction of shot-to-shot phase-variation and motion. Diffusion-PEPTIDE is demonstrated here to enable distortion-free in vivo diffusion-relaxometry with large parameter space in an sensible acquisition time.

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