Abstract #0953

Diffusion-PEPTIDE: rapid distortion-free diffusion-relaxometry imaging

Merlin J Fair^1,2, Congyu Liao^1,2, Daeun Kim³, Divya Varadarajan^1,2, Justin P Haldar^3,4, and Kawin Setsompop^1,2,5

¹A. A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, ²Department of Radiology, Harvard Medical School, Boston, MA, United States, ³Department of Electrical and Computer Engineering, University of Southern California, Los Angeles, CA, United States, ⁴Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ⁵Harvard-MIT Health Sciences and Technology, MIT, Cambridge, MA, United States

Diffusion-PEPTIDE incorporates the recently developed rapid multi-shot relaxometry technique Propeller EPTI with Dynamic Encoding (PEPTIDE) into a diffusion acquisition scheme. PEPTIDE enables fast acquisition of distortion- and blurring-free images, time-resolved for different timepoints with varying T2 & T2* weighting, with self-navigation for correction of shot-to-shot phase-variation and motion. Diffusion-PEPTIDE is demonstrated here to enable distortion-free in vivo diffusion-relaxometry with large parameter space in an sensible acquisition time.

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