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Abstract #0954

Diffusion-weighted phase imaging: towards a tract-specific myelin measure

Michiel Cottaar1, Benjamin C. Tendler1, Wenchuan Wu1, Karla L. Miller1, and Saad Jbabdi1
1WIN@FMRIB, University of Oxford, Oxford, United Kingdom

We propose a novel sequence that adds a second asymmetric spin echo after a standard Stejskal-Tanner sequence. This allows the estimation of the off-resonance frequency of the diffusion-weighted signal due to the myelin magnetic susceptibility. Varying the orientation of the diffusion-weighting gradient dephases different fibre populations. In simulations we show that for a sufficiently high b-value (>~3 ms/μm2), the intra-axonal water will dominate leading to a simple relation between the myelin-induced frequency shift and the log g-ratio. This allows the difference in log g-ratio between crossing fibres to be measured and hence estimate the myelination of individual crossing tracts.

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