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Abstract #1010

Myelin-sensitive Quantitative Maps: Two’s Company, Three’s a Crowd?

Matteo Mancini1,2,3, Eva Alonso-Ortiz2, Mara Cercignani1, Julien Cohen-Adad2, and Nikola Stikov2
1Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, United Kingdom, 2NeuroPoly Lab, Polytechnique Montreal, Montreal, QC, Canada, 3CUBRIC, Cardiff University, Cardiff, United Kingdom

Are myelin-sensitive maps interchangeable? We performed a scan-rescan study in 5 subjects using T1 mapping, magnetization transfer and myelin water fraction. We found overall that all metrics have high scan-rescan repeatability and that they are highly correlated with each other. However, isolating the main factor behind this shared variance is not straightforward because of the different interplays between the measures. In the end, what will matter is to what extent these relationships are preserved in the presence of pathology.

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