Abstract #1011

Large-scale quantitative atlases over the whole adult age range

Gian Franco Piredda^1,2,3, Peipeng Liang⁴, Tom Hilbert^1,2,3, Hongjian He⁵, Jean-Philippe Thiran^2,3, Yi Sun⁶, Jianhui Zhong^5,7, Kuncheng Li^8,9, and Tobias Kober^1,2,3

¹Advanced Clinical Imaging Technology, Siemens Healthcare AG, Lausanne, Switzerland, ²Department of Radiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland, ³LTS5, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland, ⁴School of Psychology, Capital Normal University, Beijing Key Laboratory of Learning and Cognition, Beijing, China, ⁵Center for Brain Imaging Science and Technology, Key Laboratory for Biomedical Engineering of Ministry of Education, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, Zhejiang, China, ⁶MR Collaboration, Siemens Healthcare Ltd., Shanghai, China, ⁷Department of Imaging Sciences, University of Rochester, Rochester, NY, United States, ⁸Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China, ⁹Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Beijing, China

It was recently shown that brain atlases of normative relaxation times enable automated detection of tissue alterations on a single-subject basis. In this work, normative quantitative T₁ and T₂ atlases were obtained from a large-scale adult cohort of healthy volunteers (#997) covering a comprehensive age range (19-72y) in a multi-centric study including eleven sites. Atlases were derived by linearly modelling the inter-subject variability of T₁/T₂ while accounting for effects such as gender and age differences. Travelling subjects were scanned in nine centers with the same protocol, the comparison of the acquired maps showed good reproducibility of the employed relaxometry sequences.

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