Here, we present a tool and reconstruction method to label white matter pathways directly on structural images without the need for diffusion MRI or tractography. A 3D U-net was trained utilizing 1109 scan sessions where fiber pathways were segmented using two different segmentation schemes. Results on testing datasets show anatomically viable segmentations and moderate-to-high volume overlaps with gold-standard pathways, on par with scan-rescan reproducibility of tractography on the same datasets. We envision the use of this tool for visualizing the expected course of white matter pathways when diffusion data are not available.
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