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Abstract #1059

Treatment efficacy of asymptomatic carotid artery stenosis patients evaluated by clinically applicable hemodynamic MRI and cognitive testing

Stephan Kaczmarz1,2, Jens Göttler1,2,3, Jan Petr4, Nico Sollmann1, Lena Schmitzer1, Andreas Hock5, Mikkel Bo Hansen6, Kim Mouridsen6, Claus Zimmer1, Fahmeed Hyder2, and Christine Preibisch1,7
1School of Medicine, Department of Neuroradiology, Technical University of Munich, Munich, Germany, 2MRRC, Yale University, New Haven, CT, United States, 3School of Medicine, Department of Radiology, Technical University of Munich, Munich, Germany, 4Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, 5Philips Healthcare, Hamburg, Germany, 6Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark, 7School of Medicine, Clinic of Neurology, Technical University of Munich, Munich, Germany

Hemodynamic MRI is highly promising to improve treatment decisions in asymptomatic internal carotid artery stenosis (ICAS). However, treatment efficacy evaluations require clinically applicable techniques, such as dynamic susceptibility contrast (DSC) and resting-state BOLD-based evaluations of amplitude of low-frequency fluctuations (ALFF). We present data from 16 asymptomatic ICAS patients before and after treatment and 17 age-matched healthy controls measuring cerebral blood volume (CBV) and capillary transit-time heterogeneity (CTH) by DSC and ALFF with additional cognitive testing. We hypothesized recovery of hemodynamic impairments after revascularization. Our results confirmed this hypothesis for all parameters. Interestingly, at the same time cognitive function remained impaired.

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