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Abstract #1067

Association of conventional vascular risk factors with asymptomatic and symptomatic intracranial atherosclerosis

Yongjun Han1,2, Runhua Zhang3, DanDan Yang1,2, Hualu Han2, Huiyu Qiao2, Dongye Li4, Shuo Chen2, Gaifen Liu3, and Xihai Zhao2
1Center for Brain Disorders Research, Capital Medical University and Beijing Institute of Brain Disorders, Beijing, China, 2Center for Biomedical Imaging Research, Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing, China, 3Department of Neurology, Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases, Beijing, China, 4Department of radiology, Sun Yat-sen Memorial hospital, Sun Yat-sen University, Beijing, China

This study investigated the association of vascular risk factors with asymptomatic and symptomatic ICAD using MR vascular wall imaging. Compared with controls, there was a positive association between hypertension and asymptomatic ICAD; and a positive association of hypertension, LDL, and diabetes and an inverse association of HDL with symptomatic ICAD (all p<0.05). Compared to asymptomatic ICAD, there was an inverse association between hyperlipidemia and symptomatic ICAD (p<0.001). We found that hypertension was a risk factor of asymptomatic ICAD and hypertension, diabetes and higher LDL were risk factors for symptomatic ICAD, whereas HDL was inversely associated with symptomatic ICAD.

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