Cerebral vascular reserve, which indicates the potential of the tissue to receive more blood flow when needed, is desired to evaluate the ischemic risk of brain tissue. However, it is cumbersome to measure vascular reserve using the current methods with Diamox or hypercapnia challenges. Therefore there is a growing interest in using resting-state MRI data to measure cerebrovascular reactivity (CVR). Here, using CO2-inhalation MRI as a gold standard and capitalizing on a large cohort of healthy controls (N=170) and Moyamoya patients (N=50), we sought to identify the optimal strategies for resting-state CVR mapping and establish benchmarks for this new technique.
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