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Abstract #1068

Cerebrovascular reactivity mapping using resting-state fMRI: comparison with CO2-inhalation method in 170 controls and 50 Moyamoya patients

Gongkai Liu1, Hanzhang Lu1, Yang Li1, Binu Thomas2, Marco Pinho2, Judy Huang1, Babu G. Welch2, Denise C. Park3, and Peiying Liu1
1Department of Radiology, Johns Hopkins University School of medicine, Baltimore, MD, United States, 2University of Texas Southwestern Medical Center, Dallas, TX, United States, 3The University of Texas at Dallas, Dallas, TX, United States

Cerebral vascular reserve, which indicates the potential of the tissue to receive more blood flow when needed, is desired to evaluate the ischemic risk of brain tissue. However, it is cumbersome to measure vascular reserve using the current methods with Diamox or hypercapnia challenges. Therefore there is a growing interest in using resting-state MRI data to measure cerebrovascular reactivity (CVR). Here, using CO2-inhalation MRI as a gold standard and capitalizing on a large cohort of healthy controls (N=170) and Moyamoya patients (N=50), we sought to identify the optimal strategies for resting-state CVR mapping and establish benchmarks for this new technique.

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