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Abstract #1077

Heat Maps of Abnormal Intracranial Hemodynamics in Intracranial Atherosclerotic Disease using 4D Flow MRI

Yue Ma1,2, Maria Aristova1, Sameer Ansari1,3,4, Ann Ragin1, Michael Markl1, and Susanne Schnell1
1Radiology, Northwestern University, Chicago, IL, United States, 2Radiology, Shengjing Hospital of China Medical University, Shenyang, China, 3Neurology, Northwestern University, Chicago, IL, United States, 4Neurosurgery, Northwestern University, Chicago, IL, United States

Symptomatic intracranial atherosclerotic disease (ICAD) patients who present with stenosis and hemodynamic abnormalities are at higher risk of recurrent stroke. We propose a methodology that creates patient-specific ‘heat maps’ of abnormal hemodynamic parameters, based on intracranial dual-venc 4D flow MRI. The heat maps were created by detecting and highlighting outlier measurements from 95% confidence interval of normative parameter estimates in healthy controls. Elevated peak velocity (PV) was found in 75% of patients and 58.3% of them with abnormal PV in the uninvolved hemisphere. This novel approach to characterize intracranial hemodynamic impact may allow making patient-specific risk stratification and treatment strategies.

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