Meeting Banner
Abstract #1078

Association of Brain Biomechanics and Vascular Dynamics using 4D Flow, MRE and DENSE MRI

Leonardo A Rivera-Rivera1, Grant S Roberts1, Laura B Eisenmenger2, Oliver Wieben1,2, Sterling C Johnson3, and Kevin M Johnson1,2
1Department of Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, 2Department of Radiology, University of Wisconsin - Madison, Madison, WI, United States, 3Department of Medicine, University of Wisconsin - Madison, Madison, WI, United States

The coupling of brain biomechanics and hemodynamics is complex as it includes arterial pressure pulsations, venous and CSF flow, and tissue compliance. Experimental evidence has demonstrated alterations of each the multiple compartments in disease; however, the relationships and coupling between brain biomechanics (e.g. strain and stiffness) and vascular flow dynamics is not well characterized. This study investigates the relationships between brain blood flow, stiffness, and strain using a multi-scale brain imaging platform that includes 4D flow, MRE, and DENSE MRI. Results suggest strong correlations between blood flow, strain, and stiffness and age-related changes in these parameters.

This abstract and the presentation materials are available to 2020 meeting attendees and eLibrary customers only; a login is required.

Join Here