The number of fiber-photometry studies incorporating fMRI are rapidly increasing, as these compatible modalities have the ability to reveal neuronal ground-truths. We recently noticed that photometry recording suffers from hemodynamic contamination, leading to false negative results. In this study, we 1) demonstrate how changes in cerebrohemodynamics can yield false negative GCaMP data, 2) propose a method to derive HbO and HbR from spectrally resolved fiber-photometry, 3) validate the derive hemodynamic parameters against concurrently measured CBV and BOLD using photometry and fMRI, 4) implement the proposed correction in vivo, and 5) apply corrected photometric results to rapidly derive hemodynamic response functions.
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