Abstract #1107

Probing the neuronal and vascular origins of task contrast-dependent hemodynamic response functions

Jingyuan E Chen^1,2, Nina E Fultz¹, Gary Glover³, Bruce R Rosen^1,2, Jonathan R Polimeni^1,2, and Laura D Lewis⁴

¹Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ²Radiology, Harvard Medical School, Boston, MA, United States, ³Radiology, Stanford University, Stanford, CA, United States, ⁴Biomedical Engineering, Boston University, Boston, MA, United States

In this study, we employed concurrent EEG/fMRI to investigate the neuronal and vascular mechanisms driving task-contrast modulation of HRF shapes. Our results demonstrated that HRFs vary as a function of task contrast levels. Briefly, HRFs elicited by high-contrast stimuli exhibited delayed time-to-peaks and stronger post-stimulus undershoots that likely arose from neuronal origins, and wider full-width-at-half-maximums that were possibly driven by vascular changes.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.