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Abstract #1107

Probing the neuronal and vascular origins of task contrast-dependent hemodynamic response functions

Jingyuan E Chen1,2, Nina E Fultz1, Gary Glover3, Bruce R Rosen1,2, Jonathan R Polimeni1,2, and Laura D Lewis4
1Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, 2Radiology, Harvard Medical School, Boston, MA, United States, 3Radiology, Stanford University, Stanford, CA, United States, 4Biomedical Engineering, Boston University, Boston, MA, United States

In this study, we employed concurrent EEG/fMRI to investigate the neuronal and vascular mechanisms driving task-contrast modulation of HRF shapes. Our results demonstrated that HRFs vary as a function of task contrast levels. Briefly, HRFs elicited by high-contrast stimuli exhibited delayed time-to-peaks and stronger post-stimulus undershoots that likely arose from neuronal origins, and wider full-width-at-half-maximums that were possibly driven by vascular changes.

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